Alzheimer’s Breakthrough

If Terry Pratchett has got you pondering this devastating disease, then you may be reassured by this paper published in PNAS a few days ago… which highlights the role of insulin to halt the neurological degeneration.

Although the brain once was considered insulin insensitive, it
is now known that central nervous system insulin signaling is important for many
aspects of neuronal function, including plasticity and memory formation.

The team showed that Rosiglitazone (an insulin sensitising drug), potentiates the ability of insulin to protect synapses against ADDLs (Amyloid beta derived diffusible ligands) which are potent central nervous system neurotoxins.

It basically opens up a huge avenue of treatment for this dehumanising degenerative disease, excellent work.

One Response to “Alzheimer’s Breakthrough”

  1. Edwin says:

    I wanted to rnecmmoed a book about infertility among other things. Waiting for Daisy by Peggy Orenstein I must stress that this book is not just for mothers, infertile women etc. It is a book about being human and everyone could benefit from reading it. Would be fathers, singles, grandparents read it. Mothers -buy it. Women who choose not to have children- read it. Women who can’t have children, buy it. You will see yourself in her mirror somewhere in her book. It will make you laugh, squirm and cry and you won’t be able to put it down. It is one of those books that sticks to your ribs and you will be thinking about Peggy O and her life for awhile. Her high school boyfriend who has 15 children is great non fiction life IS better than art in this book.I too suffered from unexplained infertility and went through the fertility mill. I now have two beautiful children and I was trying to read the last 14 pages on Saturday morning while my two kids were climbing all over me and begging me to please read But not the Hippopotamus. I selfishly ignored the very children I tried for 4 years to will into being to read a book that touched on that awful, obsessive infertile I am less than a woman stale eggs time for me with a sledgehammer.Peggy O is my new literary heroine.

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